Working Group 5
Multicentre Clinical Trials and Sustainability
Led by Stephanie Rossit from University of East Anglia, UK
WG5 develops the infrastructure, partnerships and study protocols needed to translate extended reality (XR) neurorehabilitation for spatial neglect from promising research into high-quality international multicentre clinical trials.
Aims
Working Group 5 aims to transform the scientific outputs of the COST Action into collaborative international research programmes. Building on the evidence, assessment methods, treatment recommendations and common data standards developed by the other Working Groups, WG5 will design multicentre studies to evaluate the diagnostic accuracy, clinical efficacy and implementation of XR neurorehabilitation for spatial neglect and related disorders after acquired brain injury.
Our work also focuses on establishing sustainable research collaborations, identifying funding opportunities and developing a roadmap for large-scale clinical trials that extend beyond the lifetime of the COST Action.
Plan
WG5 is organised into four interconnected activities:
Research priorities and trial design
We identify the most important scientific and clinical research questions for future multicentre studies. This includes reaching consensus on study objectives, trial design, outcome measures, participant selection, and methodological standards to ensure high-quality and comparable research across countries.
Multicentre collaboration
We establish an international network of clinical and research centres interested in participating in future XR neurorehabilitation studies. This includes developing collaborations between researchers, clinicians, industry partners and patient organisations to facilitate large-scale multicentre projects.
Funding and sustainability
We identify European and international funding opportunities that support collaborative research in XR neurorehabilitation. Working Group 5 will coordinate the preparation of competitive grant applications and develop a sustainability strategy to ensure that international collaborations continue beyond the COST Action.
Implementation and translation
We work closely with the other Working Groups to ensure that future clinical trials build upon agreed assessment methods, treatment recommendations and common data standards. Our goal is to accelerate the translation of XR technologies into routine clinical practice by developing research programmes that meet the needs of clinicians, patients and healthcare systems.
Get Involved
WG5 welcomes clinicians, clinical centres, clinical trialists, researchers, statisticians, implementation scientists, industry partners, healthcare professionals and early-career researchers interested in multicentre clinical trials and the translation of XR neurorehabilitation into clinical practice.
Members can contribute to infrastructure (clinical recruiting and delivery sites for future trials), protocol development, international collaborations, identification of funding opportunities, grant writing, stakeholder engagement, implementation planning and the development of future multicentre clinical trials.
If you are a clinician, or have contacts at clinical centres who may be interested in collaborating on future funded clinical trials as part of Working Group 5 of the NeuroXRehab COST Action, please complete the following survey under the “How to Get Involved” button.
The survey takes approximately 8 minutes to complete. All responses will be treated confidentially and will help inform the development of future funding applications and international clinical trials investigating XR technologies for spatial neglect following acquired brain injury.